Researcher Spotlight
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A/Prof Teo Kee Keong, Adrian
Research Interests:
- Stem cells
- Diabetes
- Pancreatic beta cells
- Organoids
- Precision medicine
- Cell therapy
Dr Alan Prem Kumar
Research Interests:
At the NUS Yong Loo Lin School of Medicine, my research is dedicated to advancing precision oncology in breast and gynecological cancers by targeting nuclear receptor signaling and RNA helicases. By identifying predictive biomarkers and developing targeted therapeutics, my work aims to enhance drug efficacy, personalize treatment strategies, and ultimately improve patient survival and quality of life.
Dr Chris Sham Lok To
Research Interests:
Our research program explores the molecular mechanisms that underpin capsule synthesis and bacterial virulence. We sought to:
Investigate how cell-surface glycans shape pathogenicity and immune responses.
Elucidate the interplay of capsule assembly, cell envelope synthesis, and cell division.
Uncover the mechanism behind enzyme specificity that ensures the fidelity of glycan synthesis.
Innovate high-throughput systems biology methods, such as Dual Tn-seq, to map genetic interactions and define gene functions.
Dr Jiao Chunlei
Research Interests:
Discovery, engineering, and design of CRISPR and novel bacterial defense systems with the aim of developing innovative platforms for disease diagnosis and treatment.
- Mine and characterize new CRISPR or other novel defense systems
- Develop a sensitive and high-throughput RNA detection platform
- Develop a precise and highly efficient knock-in platform in eukaryotic cells
- Develop a precise and non-cytotoxic RNA knock-down platform
- Develop a long-range genome knock-out platform
- Develop a spatial, sequential RNA recording platform
Dr Shi Jiahai
- Red Blood Cell maturation and ageing, aiming for thalassemia treatment
- Red Blood Cell & Synthetic RBC therapy against anemia, autoimmune diseases, and cancers
- Non-viral gene therapy delivered by Red Blood Cell extracellular vesicle
- Al-Assisted Antibody Discovery
Dr Tan Chee Wah
Research Interests:
My lab focuses primarily on pandemic sciences, with a particular interest in ‘bat viruses’ and ‘antibodies.’ Our team leverages surrogate systems to accurately quantify neutralizing antibodies, which are key immune biomarkers responsible for protection against viral diseases. Through surveillance, we aim to identify infectious disease threats in the region and better prepare for future pandemics, including the development of universal vaccines and therapeutic antibodies.
Dr Tsai Shih-Yin
Research Interests:
- mTORC1 signaling and muscle aging: Understanding how mTORC1 pathway disrupts proteostasis and contributes to sarcopenia.
- Sex differences in muscle aging: Investigating how biological sex influences proteostasis mechanisms and responses to anti-aging interventions.
Dr Vincenzo Sorrentino
Research Interests:
My laboratory focuses on:
- Biology of aging
- Proteostasis
- Mitochondria and NAD+ metabolism
- Preclinical models of neuromuscular disease (e.g. C. elegans, cell lines, rodents).
Dr Yeo Shang Long
Research Interests:
- Ethics of nudging, ethics of behaviour change
- Clinical ethics
- Ethics of public policy
- Ethics of AI
Dr Yu Haojie
Research Interests:
My lab at NUS aims to establish an integrative and systematic approach to uncover novel regulators of cardiometabolic diseases by leveraging human GWAS data, cell type-specific eQTL, single-nucleus RNA sequencing & chromatin accessibility profiling, and CRISPR/Cas9-based functional screening.
In addition, we have a strong focus on GPCRs and their roles in disease regulation. To advance therapeutic development, we utilize high-throughput compound screening and AI-driven ‘hit-to-lead’ optimisation to identify and refine novel GPCR-targeting therapies.
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